evaluation of cytogenetic changes and flt3 mutations in patients with acute promyelocytic leukemia
نویسندگان
چکیده
introduction: the secondary genetic changes other than the pml-rara fusion gene may contribute to the acute promyelocytic leukemogenesis. chromosomal alterations and mutation of flt3 tyrosine kinase receptor are the frequent genetic alterations in acute myeloid leukemia (aml). however, the prognostic significance of flt3 mutations in acute promyelocytic leukemia (apl) is not firmly established. patients & methods: flt3 itd screening by fragment length analysis and flt3 d835 mutation by melting curve analysis in 23 apl samples was screened in this study. results: about13% of the patients had flt3 internal tandem duplications (itds), and 26% had d835 point mutation. flt3 itd mutation was associated with higher white blood cell (wbc) count at presentation and poor prognosis. conclusions: as the pml-rara is not sufficient to develop apl, we assume flt3 mutations and additional chromosomal alterations in this apl series may cooperate with pml-rara in apl development.
منابع مشابه
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Background: The secondary genetic changes other than the promyelocytic leukemia-retinoic acid receptor (PML-RARA) fusion gene may contribute to the acute promyelocytic leukemogenesis. Chromosomal alterations and mutation of FLT3 (FMS-like tyrosine kinase 3) tyrosine kinase receptor are the frequent genetic alterations in acute myeloid leukemia. However, the prognostic significance of FLT3 mutat...
متن کاملPrognostic value of FLT3 mutations in patients with acute promyelocytic leukemia treated with all-trans retinoic acid and anthracycline monochemotherapy.
BACKGROUND Fms-like tyrosine kinase-3 (FLT3) gene mutations are frequent in acute promyelocytic leukemia but their prognostic value is not well established. DESIGN AND METHODS We evaluated FLT3-internal tandem duplication and FLT3-D835 mutations in patients treated with all-trans retinoic acid and anthracycline-based chemotherapy enrolled in two subsequent trials of the Programa de Estudio y ...
متن کاملcytogenetic and fms-like tyrosine kinase 3 mutation analyses in acute promyelocytic leukemia patients
background: the secondary genetic changes other than the promyelocytic leukemia-retinoic acid receptor (pml-rara) fusion gene may contribute to the acute promyelocytic leukemogenesis. chromosomal alterations and mutation of flt3 (fms-like tyrosine kinase 3) tyrosine kinase receptor are the frequent genetic alterations in acute myeloid leukemia. however, the prognostic significance of flt3 mutat...
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عنوان ژورنال:
international journal of hematology-oncology and stem cell researchجلد ۴، شماره ۳، صفحات ۲۶-۳۳
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